5-APB is a supplementary research chemical in the benzofuran and phenethylamine family known to be an entactogenic and stimulant compound. Manufacturers developed 1-Benzofuran-5-ylpropan-2-amine for further research on compounds known as Benzofury which were created to be substituted for phenethylamine, amphetamine, and benzofuran. All of these compounds including 5-apb are known as empathogenic psychoactive compounds.

There is very little information on 5-apb as scientific studies have not been conducted to show the long-term effects of these chemicals in humans. Therefore, it is listed as a research chemical and is not intended for animal or human consumption.

The studies on 5-apb that have been conducted show that it is a reuptake inhibitor of norepinephrine, dopamine, and serotonin along with being a releasing agent for serotonin, dopamine, and norepinephrine. Other in vivo showed that 5-apb had a strong physiological response for the receptors 5-HT2-A and 5-HT2B. Through these studies, it is believed that this and other compounds that are similar may produce similar effects as MDMA after long term usage.

Until more research is done on 5-apb to discover the toxicity, potential abuse, and long-term side effects, this compound will be intended for use in controlled laboratories as other research chemicals. When more is discovered regarding how 5-apb binds to various proteins and receptors in the brain and body scientists can determine if there are any health or mental attributes for this chemical to benefit humans.

Psychoactive compounds such as 5-apb developed by manufacturers with the hopes of providing medical breakthroughs that can provide health benefits without the harmful or unpleasant side effects often seen with the parent medication. Due to this, more research can be conducted through academic, agricultural, scientific, and forensic laboratories before moving forward with other studies.