4-CMC is a research chemical that is often referred to as 4-Chloromethcathinone or Clephedrone and is classified in the cathinone class as a stimulant. The formula of 4-CMC is C10H12C1NO with an average mass of 197.661 and a monoisotopic mass of 197.061000.

In scientific studies, it has been used as an activator of ryandodine receptors as well as known as an inhibitor of SERCA CA2+ pumps that increase in the skeletal muscles cytosolic free calcium concentration. The IUPAC name for 4-C MC is 1-(4-chlorophenyl)-2-(methylamino)-1-propanone.

Research on 4-CMC was conducted by ACD/Labs’ and ChemAxon. Properties that were predicted by ACD/Labs showed two hydrogen bond acceptors, one hydrogen bond donor, three freely rotating bonds, index of refraction at 1.529 with a surface tension of 37.459 dyne/cm, a flash point of 136.924 °C and a boiling point of 302.791 °C at 760 mmHg.

Properties that were revealed concerning 4-CMC that were published by ChemAxon included a topology analysis that showed a 25 atom count, 25 bond count, 1 cyclomatic number, 7 chain atom count, 7 chain bond count, 1 asymmetric atom count, and 3 rotatable bond count. Under the geometry study of 4-CMC the information provided showed a deriding energy of 28.22 kcal/mol with a volume of 178.72 Å3, a minimal projection area of 35.55 Å2 and maximum at 56.60 Å2.

Other information compiled via studies from different laboratories regarding 4-CMC include 16 heavy atom count, 35.5 topological polar surface area, 1 covalently bonded unit count, 1 feature 3D hyrdrophobe count, 1 feature 3D ring count, and 5 effective rotor count.

4-CMC has related compounds with annotation, which includes 17 medications such as Phenylephrine, Methamphetamine, Tranylcypromine, Dextroamphetamine, Amphetamine, Ephedrine, Pseudoephedrine, and tranylcypromine, among others.

4-CMC is found in 86 literature research items including phenyleprine, 3-hydroxyehedrine, pholedrine, and tranlcypromine as examples.

4-CMC still under related compounds with annotation is found in 19 3D structures, 287 bioactivities, and 2656 patents.
When it comes to possessing 4-CMC, it is best if you learn about the laws in your country. In the United States this research chemical 4-CMC is NOT intended for human consumption and is only intended for research purposes in a controlled laboratory for scientific and forensic study, however it has not been classified at this time, but may fall under the Synthetic Drug Abuse Prevention Act of 2012, which includes a specific area for synthetic drugs under SEC. 1152, which states the Addition of Synthetic Drugs to Schedule I of the Controlled Substances Act. If 4-CEC is listed as a schedule I chemical it is due to the fact that research has not been done to accept the research chemical for use in medical treatment or the lack of acceptable safety use under the supervision of a physician and that it may cause at least a possibility for abuse.

In Canada it is a Schedule I drug, in Denmark an Anlage II, in the UK a Class B, in German 4-CMC is a controlled chemical classified under anlage II. In 2015, Sweden and China both has placed 4-CMC as an illegal narcotic.

One laboratory has 4-CMC listed as 4-Chloromethcathinone (hydrochloride) with 4-CMC and Clephedrone listed as synonyms. This laboratory classifies 4-CMC as a psychoactive cathinone that stops norepinephrine reuptake and states that it is an analogue of methcathinone that inserted a chlorine atom in the phenyl ring at 4 position.

According to this laboratory, 4-CMC is related to 3-Chloromethcathinone (hydrochloride), 4-Bromomethcathinone (hydrochloride), 4-Fluoromethcathinone (hydrochloride), and Methcathinone (hydrochloride). The related product categories include 6480 biochemicals, 168 cathinones, 1256 forensic science, and 2046 neuroscience.

When a new research chemical is discovered or created in a laboratory it is very important that you understand that this chemical like 4-CMC has not been researched long enough to ensure the safety of usage in humans or animals, therefore it is very important these chemicals are purchased by controlled laboratories as some may new research chemicals can change completely and not perform as expected if not stored properly or may become unstable.

4-CMC should be stored at -20°C or -4 Fahrenheit, which will ensure the research chemical, will remain stable for up to two years. The correct way to experiment with 4-CMC is in a forensic or scientific laboratory. There are many factors that have not been discovered regarding 4-CMC, therefore there is no proof of any type of medical benefit alone or if the chemical has a potential to become addictive which is a main concern of these chemicals. However, at this time, 4-CMC can be shipped to the United States, as it has not been classified or listed on the controlled list. It would still be a good idea to check before ordering as laws change all the time especially when it comes to research chemicals. The FDA must discover the research chemical and learn the components before making the proper decision; therefore, it is still legal at this time.